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So that could be by upgrading runes already in an item or crafting unset runes in a device with reagents or multiples of the same rune combining to ‘upgrade’ the rune.

Blizzard also appears to be using the same names and some of the visual representations of the rune symbols as seen in Diablo 2. It’s unclear if all the 33 different runes from Diablo 2 will be the same in Diablo 4. However, some have been identifies as shown in the list below.

Some of the Diablo 4 runes have been confirmed already but note, the socketed properties in Diablo 4 are different from the properties in Diablo 2. Below is a list of all the expected runes based on the Diablo 2 runes. The list shows confirmed runes for Diablo IV and their new properties.

Known Diablo 4 Runes

Rune Diablo 4 Confirmed Condition /

Effect

Socketed Properties
El
Eld X Condition When you are stunned or frozen, activate the next socketed rune
Tir
Nef
Eth X Condition Every 3 seconds without moving, activate the next socketed rune
Ith
Tal
Ral
Ort
Thul X Effect When active, gain 500 damage barrier
Amn X Condition When you freeze an enemy, activate the next socketed rune.
Sol X Effect When active, gain a random shrine effect for 7 seconds
Shael
Dol X Effect When active, gain 50% critical strike chance for 7 seconds
Hel
Io
Lum
Ko X Effect When active, reduce a random skill cooldown by 15%
Fal X Condition When a pet dies, activate the next socketed rune
Lem
Pul
Um
Mal
Ist X Effect When active, your next thorns hit deals 30% more
Gul
Vex X Condition When you use a healing potion, activate the next socketed rune
Ohm
Lo
Sur
Ber
Jah
Cham
Zod